Conivaptan HCI
Conivaptan hydrochloride
CAS: 168626-94-6
Molecular Formula: C32H26N4O2.HCl
Conivaptan HCI - Names and Identifiers
Conivaptan HCI - Physico-chemical Properties
| Molecular Formula | C32H26N4O2.HCl |
| Molar Mass | 535.04 |
| Melting Point | >250° |
| Boling Point | 751.2°C at 760 mmHg |
| Flash Point | 408.1°C |
| Solubility | Soluble in DMSO (107 mg/ml at 25 °C), ethanol (7 mg/ml at 25 °C), and water (<1 mg/ |
| Vapor Presure | 1.89E-22mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Use | A non-peptide inhibitor of antidiuretic hormone |
| In vivo study | In myocardial infarction and sham-operated rats, Conivaptan(0.03,0.1, and 0.3 mg/kg, I. V.) dose-dependently increased urine output and decreased urine osmolality. In rats with myocardial infarction, Conivaptan(0.3 mg/kg, I. V.) significantly reduced right ventricular systolic pressure, left ventricular end-diastolic pressure, lung/body weight, and right atrial pressure. In rats with myocardial infarction, Conivaptan(0.3 mg/kg, I. V.) significantly increased dP/dt (Max)/left ventricular pressure. Conivaptan produces an acute increase in urine volume (UV) and a decrease in osmolality (UOSM). At the end of the treatment, V(1a)/V(2)-AVP receptor antagonist treated cirrhotic rats did not show hyponatremia or hypotonicity. Conivaptan also restored U(Na)V without affecting creatinine clearance and blood pressure. In dogs, Conivaptan(0.01 to 0.1 mg/kg, I. V.) exerts a dose-dependent diuretic effect without increasing the urinary excretion of electrolytes, inhibited the pressor effect of exogenous vasopressin in a dose-dependent manner (0.003 to 0.1 mg/kg, I. V.) and, at the highest dose (0.1 mg/kg, I. V.), it almost completely blocks the vasoconstriction induced by exogenous vasopressin. Conivaptan(0.1 mg/kg, I. V.) improves cardiac function as evidenced by a significant increase in left ventricular dP/dt Maxima, cardiac output and stroke volume. In dogs with congestive heart failure, Conivaptan (0.1 mg/kg, I. V.) reduced anteroposterior load, as evidenced by a significant decrease in left ventricular end-diastolic pressure and total peripheral vascular resistance. |
Conivaptan HCI - Reference
| Reference Show more | 1. [IF=4.411] Xin Meng et al."Drug Repurposing for Influenza Virus Polymerase Acidic (PA) Endonuclease Inhibitor."Molecules. 2021 Jan;26(23):7326 |
Conivaptan HCI - Introduction
Conivaptan HCl is a non-peptide antidiuretic hormone inhibitor (vasopressin receptor antagonist).
Last Update：2022-10-16 17:14:20
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